Virology
Review of Virus Groups involved in Human Disease
This short animated video shows the fifth and the last stage of Herpes simplex virus infection - envelopment and release from the infected cell.
First, the viral glycoproteins are transfered via cell's RER and the Golgi apparatus to the membrane. Then, the capsid associates with Viral tegument proteins such as "Alpha tif and VHS and migrates to the membrane via RER and the Golgi apparatus. The final stage is the budding of the HSV from the infected cell through the viral glycoproteins.
The virus is now mature and is ready to infect other cells in the area.
First, the viral glycoproteins are transfered via cell's RER and the Golgi apparatus to the membrane. Then, the capsid associates with Viral tegument proteins such as "Alpha tif and VHS and migrates to the membrane via RER and the Golgi apparatus. The final stage is the budding of the HSV from the infected cell through the viral glycoproteins.
The virus is now mature and is ready to infect other cells in the area.
This is a time lapse movie of Vero cells (monkey kidney) infected with wildtype herpes simplex virus 1. The images are taken every 3 minutes over a period of several hours. The image capture was started several hours post-infection. As the virus replicates, the host cell rounds up as the cellular cytoskeleton is altered.
Note the cellular processes occurring the cytoplasm before the cells start to die.
Note how the nuclei in some cells start to spin and move around as the infection proceeds.
Also note the projections remaining between the cells even after release from the culture surface.
Note the cellular processes occurring the cytoplasm before the cells start to die.
Note how the nuclei in some cells start to spin and move around as the infection proceeds.
Also note the projections remaining between the cells even after release from the culture surface.
